Jeffrey Tambor is great in Transparent, but after about 6 episodes, I couldn't take his kids anymore. Especially the son who was banging his babysitter. But Tambor is so good, he almost makes up for it.
The son never fucks his own sister. When I read that, I almost thought I missed something, but I've been carefully watching the show since it started. Maybe you confused this with when he was sleeping with his little sister's best friend/lover played by Carrie Brownstein?
Anyway, I don't think any of the characters are supposed to be likable since they are based on real people - which is what I sort of like about the show. They are all very flawed human beings and at times you have to really stretch to find the good in them, but when you do, or when I do, there comes an awful lot of empathy as I get to understand more about them.
The kids were brought up rich and spoiled, and kept in the dark about pretty much everything. Lots of lies, yet with seemingly "open" hippie-like parents who were both very repressed themselves...it's all very interesting to me.
I also like
One Mississippi, Rectify, The Fall (whenever it comes back!), and a newer show with Pamela Adlon:
Better Things is really good too.